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Gene name:
Ang(Ang1;Rnase5;Rnase5a);
Protein name:
Angiogenin;
Alternative:
Angiogenin-1;Ribonuclease 5(RNase 5);
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.
Function:
May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Subcellular Location:
Secreted
Protein Attributes:
Sequence length:
145
Sequence:
50:
MAISPGPLFL | IFVLGLVVIP | PTLAQDDSRY | TKFLTQHHDA | KPKGRDDRYC |
100:
ERMMKRRSLT | SPCKDVNTFI | HGNKSNIKAI | CGANGSPYRE | NLRMSKSPFQ |
145:
VTTCKHTGGS | PRPPCQYRAS | AGFRHVVIAC | ENGLPVHFDE | SFFSL
Predicted Eptitope:
N/A
Related Databases
SMR:
P21570
STRING:
10090.ENSMUSP00000067434
KEGG:
mmu:11727
UniGene:
Mm.202665
Pfam:
PF00074
String:
P21570
Uniprot:
P21570